Purpose: To find out if using progesterone can help to control seizures in women with epilepsy

Inclusion criteria: Women only; Age 13-45; Has failed 2 or more antiepileptic drugs; Has at least 2 seizures/month; Not on oral contraceptives

Subjects will keep calendars of seizures and menstrual periods for a baseline period of 3 months. During the second 3 months of the study, Subjects will be randomized to progesterone or placebo lozenges which will be taken during the second half of the menstrual cycle. Subjects will have 1 or 2 appointments each month over 6 menstrual cycles at which they will have a physical exam, have blood drawn, and complete questionnaires.

Please contact Alison Randall (212-305-1684; arandall@neuro.columbia.edu).


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